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Starting too soon: upstream reading frames repress downstream translation
Author(s) -
McGeachy Anna M,
Ingolia Nicholas T
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201693946
Subject(s) - upstream open reading frame , biology , ribosome profiling , translation (biology) , open reading frame , five prime untranslated region , upstream (networking) , genetics , downstream (manufacturing) , computational biology , gene , ribosome , messenger rna , rna , computer science , peptide sequence , computer network , operations management , economics
Upstream open reading frames ( uORF s) are known to regulate a few specific transcripts, and recent computational and experimental studies have suggested candidate uORF regulation across the genome. In this issue, Johnstone et al (2016) use ribosome profiling to identify translated uORF s and measure their effects on downstream translation. Furthermore, they show that regulatory uORF s are conserved across species and subject to selective constraint. Recognizing the potential of uORF s in regulating translation expands our understanding of the dynamic regulation of gene expression.