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Agile CD 22 nanoclusters run rings around fenced BCR
Author(s) -
Depoil David,
Dustin Michael L
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201593745
Subject(s) - breakpoint cluster region , biology , nanoclusters , signalling , b cell receptor , microbiology and biotechnology , antibody , receptor , immunology , b cell , genetics , nanotechnology , materials science
B lymphocytes are key players in host defence, but also autoimmune diseases. Their survival depends upon tonic signals transduced by surface immunoglobulin ( BCR ) and the process leading to antibody secretion is initiated by interaction of BCR with a cognate antigen. CD 22 limits signalling of the BCR to strike a balance between tonic signalling, reactivity to pathogens and prevention of autoimmunity. In this issue, Gasparrini et al (2016) combined super‐resolution imaging approaches with single‐particle tracking and simulations to show how CD 22 controls the signalling state of the BCR . They demonstrated that small CD 22 nanoclusters run rings around the BCR in confined steady state to maintain low tonic signals, but releasing BCR from these corrals allows BCR cluster growth, which overcomes the harrying inhibition from highly mobile CD 22.