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Siglecs take a TOLL on inflammation: deciphering the Hsp70 riddle
Author(s) -
Calderwood Stuart K,
Murshid Ayesha
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201593172
Subject(s) - siglec , biology , inflammation , immunology , innate immune system , receptor , computational biology , microbiology and biotechnology , genetics , immune system
The manuscript by Fong et al ([Fong JJ, 2015]) in this issue of The EMBO Journal addresses an ongoing question in immunology: are extracellular HSP s endogenous inflammatory signals or are they in fact built‐in inhibitors of those same functions? In a highly original series of experiments, they identify novel Hsp70 receptors in monocytes as members of the Siglec family. Even more significantly, two Siglec family members transmitted divergent responses to Hsp70, with Siglec‐5 dampening inflammation while Siglec‐14 triggering the inflammatory cascade. These findings therefore go some way in addressing the open question: is Hsp70 pro‐ or anti‐inflammatory and leaving us with the answer yes.