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Scissors for autolysosome tubules
Author(s) -
Chen Yang,
Yu Li
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201592519
Subject(s) - beijing , china , chinese academy of sciences , library science , state (computer science) , biology , computer science , political science , algorithm , law
Autophagic lysosome reformation ( ALR ) is a cellular process in which lysosomes are reformed through scission of proto‐lysosomes from tubular structures extruded from autolysosomes. Despite recent progress, the molecular mechanism of ALR is far from clear. A paper in this issue of The EMBO Journal has identified lysosome‐localized PI (3)P, which is generated by the VPS 34– UVRAG complex in an mTOR ‐dependent manner, as an important regulator of autolysosome tubule scission (Munson et al , [Munson MJ, 2015]).