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Simply the right time to turn on insulin
Author(s) -
Spagnoli Francesca M
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201591894
Subject(s) - biology , induced pluripotent stem cell , beta cell , holy grail , transplantation , insulin , population , cancer research , diabetes mellitus , bioinformatics , medicine , endocrinology , islet , genetics , embryonic stem cell , gene , world wide web , environmental health , computer science
Recent research has made important progress in the directed differentiation of human pluripotent stem cells into insulin‐producing beta‐like cells in vitro . A new study published in this issue of The EMBO Journal reports that timely induction of NEUROG3 expression in pancreatic progenitors is a crucial checkpoint for generation of functional human beta cells.