Premium
Departure gate of acidic Ca 2+ confirmed
Author(s) -
Jentsch Thomas J,
HoeggBeiler Maja B,
Vogt Janis
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201591884
Subject(s) - excellence , medicine , physics , philosophy , epistemology
More potent, but less known than IP 3 that liberates Ca 2+ from the ER , NAADP releases Ca 2+ from acidic stores. The notion that TPC channels mediate this Ca 2+ release was questioned recently by studies suggesting that TPC s are rather PI (3,5)P 2 ‐activated Na + channels. Ruas et al (2015) now partially reconcile these views by showing that TPC s significantly conduct both cations and confirm their activation by both NAADP and PI (3,5)P 2 . They attribute the failure of others to observe TPC ‐dependent NAADP ‐induced Ca 2+ release in vivo to inadequate mouse models that retain partial TPC function.