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p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration
Author(s) -
GonzálezTerán Bárbara,
Matesanz Nuria,
Nikolic Ivana,
Verdugo María Angeles,
Sreeramkumar Vinatha,
HernándezCosido Lourdes,
Mora Alfonso,
Crainiciuc Georgiana,
Sáiz María Laura,
Bernardo Edgar,
LeivaVega Luis,
Rodríguez Elena,
Bondía Victor,
Torres Jorge L,
PerezSieira Sonia,
Ortega Luis,
Cuenda Ana,
SanchezMadrid Francisco,
Nogueiras Rubén,
Hidalgo Andrés,
Marcos Miguel,
Sabio Guadalupe
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201591857
Subject(s) - fatty liver , biology , insulin resistance , steatosis , inflammation , fibrosis , steatohepatitis , endocrinology , liver disease , medicine , immunology , obesity , disease , biochemistry
Non‐alcoholic fatty liver disease ( NAFLD ) is a major health problem and the main cause of liver disease in Western countries. Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood. The disease begins with an excessive accumulation of triglycerides in the liver, which stimulates an inflammatory response. Alternative p38 mitogen‐activated kinases (p38γ and p38δ) have been shown to contribute to inflammation in different diseases. Here we demonstrate that p38δ is elevated in livers of obese patients with NAFLD and that mice lacking p38γ/δ in myeloid cells are resistant to diet‐induced fatty liver, hepatic triglyceride accumulation and glucose intolerance. This protective effect is due to defective migration of p38γ/δ‐deficient neutrophils to the damaged liver. We further show that neutrophil infiltration in wild‐type mice contributes to steatosis development by means of inflammation and liver metabolic changes. Therefore, p38γ and p38δ in myeloid cells provide a potential target for NAFLD therapy.