Premium
A grab to move on: ER –endosome contacts in membrane protrusion formation and neurite outgrowth
Author(s) -
Krauß Michael,
Haucke Volker
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201591553
Subject(s) - biology , endosome , neurite , microbiology and biotechnology , transport protein , vesicular transport proteins , genetics , in vitro , intracellular , vacuolar protein sorting
A key feature of many eukaryotic cells, most prominently seen in developing neurons, is their ability to form and extend membrane protrusions. How protrusion formation is linked to exocytic membrane trafficking is largely unclear. In a recent paper published in Nature, Raiborg et al identify a crucial role in this process for dynamic membrane contact sites ( MCS s) between the ER and endosomes. The MCS s are formed by endoplasmic reticulum ( ER )‐localized protein protrudin and the late endosomal kinesin adaptor FYCO 1 and the small GTP ase Rab7.