Tregs strip dendritic cells of CD 70 to regulate Th1 differentiation

When the immune system encounters an antigen, the response can result in the mobilization of effector cells or in tolerance. The outcome is largely dependent on immunosuppressive CD 4 T cells that express the transcription factor Foxp3 (Tregs). Yet, how Tregs control different immune effector cells remains elusive. In this issue of The EMBO Journal , Dhainaut et al report on a novel mechanism used by Tregs to prevent differentiation of naïve CD 4 T cells to proinflammatory Th1 CD 4 (Th1) effectors.