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Tregs strip dendritic cells of CD 70 to regulate Th1 differentiation
Author(s) -
Wojciech Lukasz,
Ignatowicz Leszek
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201591547
Subject(s) - biology , microbiology and biotechnology , cellular differentiation , immunology , genetics , gene
When the immune system encounters an antigen, the response can result in the mobilization of effector cells or in tolerance. The outcome is largely dependent on immunosuppressive CD 4 T cells that express the transcription factor Foxp3 (Tregs). Yet, how Tregs control different immune effector cells remains elusive. In this issue of The EMBO Journal , Dhainaut et al report on a novel mechanism used by Tregs to prevent differentiation of naïve CD 4 T cells to proinflammatory Th1 CD 4 (Th1) effectors.