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Blocking integrin inactivation as an anti‐angiogenic therapy
Author(s) -
Saharinen Pipsa,
Ivaska Johanna
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201591504
Subject(s) - library science , biology , computer science
During angiogenesis, endothelial cell migration is coordinated by integrin‐mediated contact with the extra‐cellular matrix ( ECM ), coupled with receptor tyrosine kinase signalling to regulate dynamic cytoskeletal and plasma membrane reorganization. A recent paper by Vitorino et al ([Vitorino P, 2015]) defined a new MAP 4K4–moesin–talin–β1‐integrin pathway that could be therapeutically exploited to suppress pathologic angiogenesis.