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Talk among yourselves: RNA sponges mediate cross talk between functionally related messenger RNA s
Author(s) -
Azam Muhammad S,
Vanderpool Carin K
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201591492
Subject(s) - biology , rna , messenger rna , five prime cap , microbiology and biotechnology , genetics , non coding rna , gene
When Francis Crick first proposed the central dogma, he predicted that genetic information flows from DNA to RNA and finally to proteins. By this classical concept, the sole purpose of mRNA is to serve as a template for translation. Recent work has expanded our understanding of the function of mRNA well beyond this singular definition. A paper published in this issue sheds more light on the myriad roles mRNA s can play in genetic regulation. Miyakoshi et al ([Miyakoshi M, 2015a]) report an intriguing scenario in Salmonella where a small RNA molecule derived from a larger polycistronic mRNA promotes cross talk between physically unlinked mRNA s via controlling turnover of a global small RNA repressor.