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Presynapses go nuclear!
Author(s) -
Kravchick Dana O,
Jordan Bryen A
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201591331
Subject(s) - einstein , library science , classics , medicine , psychology , neuroscience , physics , history , computer science , mathematical physics
Decades of research has shown that long‐term changes in synaptic function ultimately require changes in gene expression. Recent work has focused on nuclear signaling by calcium and protein messengers initiated at postsynaptic sites. In this issue of The EMBO Journal , Ivanova and colleagues show that shuttling of Ct BP ‐1 between presynaptic areas and nuclei regulates gene expression, which reminds us that presynaptic zones should not be ignored when considering synapse‐to‐nucleus signaling.