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Interrupting synoviolin play at the ER : a plausible action to elevate mitochondrial energetics and silence obesity
Author(s) -
Soustek Meghan S,
Puigserver Pere
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201591240
Subject(s) - silence , cancer , biology , genetics , art , aesthetics
Obesity is a global concern, which has been linked to increased risk for cardiovascular disease, type 2 diabetes, atherosclerosis, non‐alcoholic fatty liver, and cancer. In this issue of The EMBO Journal , Fujita et al ([Fujita H, 2015]) describe the role of an endoplasmic reticulum ( ER )‐resident E3 ubiquitin ligase, synoviolin, and its ability to control body weight and energy expenditure by targeting PGC ‐1β, a transcriptional modulator of mitochondrial oxidative metabolism.