Premium
Creating cellular diversity through transcription factor competition
Author(s) -
Göttgens Berthold
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201591017
Subject(s) - biology , transcription factor , mesoderm , haematopoiesis , microbiology and biotechnology , progenitor cell , embryonic stem cell , stem cell , genetics , computational biology , gene
The development of blood cells has long served as a model system to study the generation of diverse mature cells from multipotent progenitors. The article by Org et al (2015) reveals how transcription factor competition on primed DNA templates may contribute to embryonic blood cell specification during the early stages of mesoderm development. The study not only provides new insights into the functionality of the key haematopoietic transcription factor Scl/Tal1, but also provides a potentially widely applicable framework for transcription factor‐mediated cell fate specification.