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Transcription factor‐mediated reprogramming toward hematopoietic stem cells
Author(s) -
Ebina Wataru,
Rossi Derrick J
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201490804
Subject(s) - biology , reprogramming , transcription factor , haematopoiesis , stem cell , microbiology and biotechnology , genetics , gene
De novo generation of human hematopoietic stem cells ( HSC s) from renewable cell types has been a long sought‐after but elusive goal in regenerative medicine. Paralleling efforts to guide pluripotent stem cell differentiation by manipulating developmental cues, substantial progress has been made recently toward HSC generation via combinatorial transcription factor ( TF )‐mediated fate conversion, a paradigm established by Yamanaka's induction of pluripotency in somatic cells by mere four TF s. This review will integrate the recently reported strategies to directly convert a variety of starting cell types toward HSC s in the context of hematopoietic transcriptional regulation and discuss how these findings could be further developed toward the ultimate generation of therapeutic human HSC s.