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Emergence of cancer stem cells in hepatocellular carcinoma
Author(s) -
Pilz Sahra,
Schotta Gunnar
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201490785
Subject(s) - biology , cancer , library science , progenitor cell , stem cell , cancer research , genetics , computer science
Liver cancer represents the second most deadly human malignancy. The major histological subtype called hepatocellular carcinoma ( HCC ) arises by chronic inflammation‐triggered regenerative responses of normally quiescent hepatocytes and progenitors, respectively. Such regenerative stress accelerates the accumulation of genetic and epigenetic changes (Yamashita & Wang, [Yamashita T, 2013]), while detailed mechanisms remain uncertain. In this issue of The EMBO Journal , Nikolaou et al present a novel HCC model that facilitates both isolation and molecular characterization of self‐renewing, HCC ‐propagating cancer stem cells that could instruct future interventions (Nikolaou et al , [Nikolaou KC, 2014]).