Premium
Cellular stress response cross talk maintains protein and energy homeostasis
Author(s) -
Swan Cynthia L,
Sistonen Lea
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201490757
Subject(s) - biology , energy homeostasis , homeostasis , microbiology and biotechnology , energy (signal processing) , genetics , statistics , receptor , mathematics
Maintenance of cellular homeostasis depends upon several pathways that allow a cell to respond and adapt to both environmental stress and changes in metabolic status. New work in this issue of The EMBO Journal reveals a mechanism of cross talk between heat shock factor 1 ( HSF 1), the primary regulator of the proteotoxic stress response, and AMP ‐activated protein kinase ( AMPK ), the primary sensor in the metabolic stress response.