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Application of biomaterials to advance induced pluripotent stem cell research and therapy
Author(s) -
Tong Zhixiang,
Solanki Aniruddh,
Hamilos Allison,
Levy Oren,
Wen Kendall,
Yin Xiaolei,
Karp Jeffrey M
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201490756
Subject(s) - medical school , medicine , regenerative medicine , stem cell , library science , gerontology , medical education , biology , computer science , genetics
Derived from any somatic cell type and possessing unlimited self‐renewal and differentiation potential, induced pluripotent stem cells ( iPSC s) are poised to revolutionize stem cell biology and regenerative medicine research, bringing unprecedented opportunities for treating debilitating human diseases. To overcome the limitations associated with safety, efficiency, and scalability of traditional iPSC derivation, expansion, and differentiation protocols, biomaterials have recently been considered. Beyond addressing these limitations, the integration of biomaterials with existing iPSC culture platforms could offer additional opportunities to better probe the biology and control the behavior of iPSC s or their progeny in vitro and in vivo . Herein, we discuss the impact of biomaterials on the iPSC field, from derivation to tissue regeneration and modeling. Although still exploratory, we envision the emerging combination of biomaterials and iPSC s will be critical in the successful application of iPSC s and their progeny for research and clinical translation.