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An ER clamp for endosome fission
Author(s) -
Raiborg Camilla,
Stenmark Harald
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201490707
Subject(s) - biomedicine , university hospital , library science , medicine , family medicine , biology , computer science , genetics
Endosomes are known to undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. A recent paper (Rowland et al , [Rowland AA, 2014]) shows that contact sites between endosomes and the endoplasmic reticulum ( ER ) define the position and timing for fission. This uncovers an unanticipated role for the ER in controlling endosomal sorting and maturation.