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Autophagy mediates nonselective RNA degradation in starving yeast
Author(s) -
Welter Evelyn,
Elazar Zvulun
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201490621
Subject(s) - autophagy , rna , biology , yeast , ribosome , protein degradation , microbiology and biotechnology , biochemistry , gene , apoptosis
During nitrogen starvation, a nonselective bulk degradation of cytosolic proteins and organelles including ribosomes, termed macro‐autophagy (hereafter termed autophagy), is induced. The precise mechanism of RNA degradation by this pathway has not been yet elucidated. In this issue of the The EMBO Journal , Huang et al characterize an autophagy‐dependent RNA catabolism in yeast and identify the enzymes responsible for the degradation process.