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There is an expanding list of examples by which one  mRNA  can posttranscriptionally influence the expression of others. This can involve  RNA  sponges that sequester regulatory  RNA s of  mRNA s in the same regulon, but the underlying molecular mechanism of such  mRNA  cross talk remains little understood. Here, we report sponge‐mediated  mRNA  cross talk in the posttranscriptional network of GcvB, a conserved Hfq‐dependent small  RNA  with one of the largest regulons known in bacteria. We show that  mRNA  decay from the  glt IJKL   locus encoding an amino acid  ABC  transporter generates a stable fragment (SroC) that base‐pairs with GcvB. This interaction triggers the degradation of GcvB by  RN ase E, alleviating the GcvB‐mediated  mRNA  repression of other amino acid‐related transport and metabolic genes. Intriguingly, since the  glt IJKL    mRNA  itself is a target of GcvB, the SroC sponge seems to enable both an internal feed‐forward loop to activate its parental  mRNA  in  cis  and activation of many  trans ‐encoded  mRNA s in the same pathway. Disabling this  mRNA  cross talk affects bacterial growth when peptides are the sole carbon and nitrogen sources.

Cross talk between ABC transporter m RNA s via a target m RNA ‐derived sponge of the G cv B small RNA