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Orphan enzyme cuts down on sugar
Author(s) -
Urban Siniša
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201490452
Subject(s) - biology , proteolysis , glycosylation , enzyme , biochemistry , glycosyltransferase , golgi apparatus , glycan , protease , microbiology and biotechnology , cell , glycoprotein
The reclusive enzymes that catalyze proteolysis inside the cell membrane are among the most widespread in nature, yet most remain ‘orphans’ whose cellular functions are poorly understood. Now, Voss et al identify Golgi‐resident glycosyltransferases and glycosidases as substrates for the presenilin‐like protease SPPL 3. Shedding of these glycan‐modifying enzymes from the membrane down‐regulates global protein N‐glycosylation.