MALT 1 protease: equilibrating immunity versus tolerance | Zendy

Bertossi Arianna | Zendy; Krappmann Daniel | Zendy

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MALT 1 protease: equilibrating immunity versus tolerance

Author(s) -

Bertossi Arianna,

Krappmann Daniel

Publication year - 2014

Publication title -

the embo journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.484

H-Index - 392

eISSN - 1460-2075

pISSN - 0261-4189

DOI - 10.15252/embj.201490217

Subject(s) - biology , protease , acquired immune system , immunity , innate immune system , immune system , function (biology) , microbiology and biotechnology , immunology , enzyme , biochemistry

MALT 1 paracaspase links signaling cascades emanating from adaptive or innate immune receptors to the canonical NF ‐κB pathway. Now, Jaworski et al ([Jaworski M, 2014]) investigate the physiological role of MALT 1 protease activity in mice. Besides the expected requirement of MALT 1 activity for immune activation, the study unveils a novel function for MALT 1 activity for the development of peripheral tolerance. Thus, MALT 1 protease can act immunogenic or tolerogenic, and this interplay will be highly relevant for the clinical development of MALT 1 inhibitors.

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