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DUB s counteract parkin for efficient mitophagy
Author(s) -
Dikic Ivan,
Bremm Anja
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201490101
Subject(s) - biology , parkin , mitophagy , microbiology and biotechnology , ubiquitin protein ligases , genetics , autophagy , ubiquitin , ubiquitin ligase , medicine , gene , apoptosis , disease , parkinson's disease
The Parkinson's disease‐associated ubiquitin E3 ligase parkin impacts various cellular processes including the autophagic clearance of defective mitochondria. In this issue of The EMBO Journal , Durcan et al ([Durcan TM, 2014]) reveal a novel control mechanism of parkin‐mediated mitophagy via the selective removal of atypical K6‐linked ubiquitin chains from parkin by the deubiquitinase USP 8. Together with recent studies on USP 15 and USP 30, this establishes a functional role for deubiquitination in mitophagy regulation.