The RAS and YAP1 dance, who is leading? | Zendy

Corbo Vincenzo | Zendy; PonzSarvise Mariano | Zendy; Tuveson David A | Zendy

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The RAS and YAP1 dance, who is leading?

Author(s) -

Corbo Vincenzo,

PonzSarvise Mariano,

Tuveson David A

Publication year - 2014

Publication title -

the embo journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.484

H-Index - 392

eISSN - 1460-2075

pISSN - 0261-4189

DOI - 10.15252/embj.201490014

Subject(s) - spring (device) , yap1 , biology , art history , library science , history , engineering , computer science , transcription factor , gene , mechanical engineering , biochemistry

The Hippo‐signaling effector YAP 1 was recently found to compensate for oncogenic RAS in certain neoplasms, suggesting so far unanticipated molecular interplays between these major signaling routes. A new study in this issue of The EMBO Journal details KRAS ‐dependent control of YAP 1 stability as well as positive feedback regulation via the RAS / YAP 1/ EGFR ‐ligand axis as novel molecular mechanisms that could become exploitable for therapeutic strategies.

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