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The RAS and YAP1 dance, who is leading?
Author(s) -
Corbo Vincenzo,
PonzSarvise Mariano,
Tuveson David A
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201490014
Subject(s) - spring (device) , yap1 , biology , art history , library science , history , engineering , computer science , transcription factor , gene , mechanical engineering , biochemistry
The Hippo‐signaling effector YAP 1 was recently found to compensate for oncogenic RAS in certain neoplasms, suggesting so far unanticipated molecular interplays between these major signaling routes. A new study in this issue of The EMBO Journal details KRAS ‐dependent control of YAP 1 stability as well as positive feedback regulation via the RAS / YAP 1/ EGFR ‐ligand axis as novel molecular mechanisms that could become exploitable for therapeutic strategies.