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Splicing together sister chromatids
Author(s) -
Valcárcel Juan,
Malumbres Marcos
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201489988
Subject(s) - biology , sister chromatids , spliceosome , rna splicing , cohesin , genetics , alternative splicing , establishment of sister chromatid cohesion , microbiology and biotechnology , mitosis , chromosome segregation , kinetochore , gene , computational biology , chromosome , exon , rna
Splicing of pre‐ mRNA s is a necessary step for expression of the majority of genes in higher eukaryotes, and its regulation through alternative splice site selection shapes their proteomes. Defects in multiple splicing factors result in aberrant mitotic progression, although the molecular basis for this observation has remained elusive. Recent papers in The EMBO Journal and EMBO Reports reveal that expression of sororin, a critical regulator that stabilizes cohesin rings in sister chromatids, is exquisitely sensitive to defects in the splicing machinery, thus explaining the striking link between spliceosome function and chromosome segregation.