Premium
Old dog, new tricks: Arf1 required for mitochondria homeostasis
Author(s) -
Rabouille Catherine
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201489899
Subject(s) - biology , mitophagy , mitochondrion , microbiology and biotechnology , autophagy , golgi apparatus , vesicle , membrane , endoplasmic reticulum , biochemistry , apoptosis
The small GTP ase Arf1 that is classically required for the budding of COPI ‐coated vesicles from the Golgi membrane is now proposed to have novel and conserved roles in the morphological and functional maintenance of mitochondria: It functionally localizes to ER /mitochondria contact sites; it allows for the recruitment of a degradation machinery to mitochondria to remove toxic mitofusin/Fzo1 clusters; and it allows the extension of autophagy sequestration membranes needed for mitophagy to clear damaged mitochondria.