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LRRK 2 directing ER ‐to‐ G olgi transport? ( ER )y ES !
Author(s) -
Lu Bingwei
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201489832
Subject(s) - lrrk2 , biology , mutation , genetics , gene
Mutations in leucine‐rich repeat kinase 2 ( LRRK 2) represent the most frequent genetic lesions associated with Parkinson's disease ( PD ). LRRK 2 function and the pathogenic mechanisms of LRRK 2 genetic mutations remain poorly understood. Cho et al report in this issue of The EMBO Journal a new interaction between LRRK 2 and the ER exit site ( ERES ) protein Sec16A, important for anterograde transport of secretory proteins. Moreover, a disease‐associated mutation disrupts LRRK 2–Sec16A interaction and ERES function.