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Stem cell competition: how speeding mutants beat the rest
Author(s) -
Morrissey Edward R,
Vermeulen Louis
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201489823
Subject(s) - biology , rest (music) , beat (acoustics) , mutant , stem cell , competition (biology) , genetics , microbiology and biotechnology , gene , medicine , ecology , physics , acoustics
How mutations lead to tumor formation is a central question in cancer research. Although cellular changes that follow the occurrence of common mutations are well characterized, much less is known about their effects on the population level. Now, two recent studies reveal in what way oncogenic aberrations alter stem cell dynamics to provide cells with an evolutionary advantage over their neighbors (Amoyel et al , [Amoyel M, 2014]; Baker et al , [Baker AM, 2014]).