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A near death experience: Shigella manipulates host death machinery to silence innate immunity
Author(s) -
Bronner Denise N,
O'Riordan Mary XD
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201489680
Subject(s) - biology , innate immune system , immunity , silence , shigella , host (biology) , immunology , ecology , immune system , salmonella , genetics , bacteria , aesthetics , philosophy
Release of mitochondrial contents often triggers inflammation and cell death, and modulating this process can be advantageous to invading pathogens. In this issue of The EMBO Journal , Andree and colleagues reveal new findings that an intracellular bacterial pathogen exploits apoptotic machinery to suppress host immune signaling, yet avoids cell death. This study emphasizes the need to expand our understanding of the roles played by pro‐apoptotic proteins in non‐death scenarios.