Premium
Primary pi RNA biogenesis: caught up in a Maelstrom
Author(s) -
Pandey Radha Raman,
Pillai Ramesh S
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201489670
Subject(s) - rna , biology , biogenesis , cytoplasm , non coding rna , rna editing , microbiology and biotechnology , rna dependent rna polymerase , small nuclear rna , rna binding protein , piwi interacting rna , genetics , gene , rna interference
Precursors for most Piwi‐interacting RNA s (pi RNA s) are indistinguishable from other RNA polymerase II ‐transcribed long non‐coding RNA s. So, it is currently unclear how they are recognized as substrates by the pi RNA processing machinery that resides in cytoplasmic granules called nuage. In this issue, Castaneda et al (2014) reveal a role for the nuage component and nucleo‐cytoplasmic shuttling protein Maelstrom in mouse pi RNA biogenesis.