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Traffic control: adaptor proteins guide dynein–cargo takeoff
Author(s) -
Cianfrocco Michael A,
Leschziner Andres E
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201489450
Subject(s) - dynein , biology , dynactin , processivity , microtubule , signal transducing adaptor protein , microbiology and biotechnology , motor protein , molecular motor , cytoskeleton , transport protein , genetics , cell , signal transduction , gene , dna replication
The precise movement of intracellular components requires active transport by molecular motors along the filamentous tracks of the cytoskeleton. While yeast cytoplasmic dynein can walk for some distance along microtubules, mammalian dynein is non‐processive. This has raised the question of how this motor can transport cargo. In two recent papers by the Carter, Bullock and Vale labs, mammalian dynein processivity has now been successfully reconstituted in vitro in the presence of adaptor proteins.