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Integration of microenvironmental and stress signaling antagonizes colorectal cancer progression
Author(s) -
Linde Nina,
Sosa Maria Soledad,
AguirreGhiso Julio A
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201489364
Subject(s) - medicine , hematology , otorhinolaryngology , oncology , cancer , colorectal cancer , family medicine , surgery
Genetic alterations can drive oncogenic events and cancer development. However, this is only half of the story. It is now evident that tumor progression only occurs if powerful stress signaling pathways and microenvironmental signals are overcome. Two recent Nature Cell Biology papers study how niche signals of primary and target organ barriers have to be overridden for oncogenes to allow for colorectal cancer ( CRC ) initiation and metastasis (Urosevic et al , [Urosevic J, 2014]; Whissell et al , [Whissell G, 2014]).