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Location, location, and location: compartmentalization of Hedgehog signaling at primary cilia
Author(s) -
Pusapati Ganesh V,
Rohatgi Rajat
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201489294
Subject(s) - cilium , biology , hedgehog , intraflagellar transport , microbiology and biotechnology , compartmentalization (fire protection) , ciliogenesis , microtubule , hedgehog signaling pathway , signal transduction , wnt signaling pathway , kinesin , organelle , compartment (ship) , transcription factor , regulator , flagellum , genetics , gene , biochemistry , oceanography , geology , enzyme
Primary cilia are solitary, microtubule‐based organelles that serve as signaling hubs for the Hedgehog (Hh) pathway, which regulates embryonic development and adult tissue homeostasis. While protein localization studies have suggested that the dynamic trafficking of Hh components at cilia plays an important role, the molecular basis of Hh signal transduction at cilia is not well understood. In a recent study published in Nature Cell Biology (He et al , 2014), He and colleagues demonstrate that the kinesin KIF 7, a conserved regulator of Hh signaling, limits ciliary length by acting at the plus‐ends of microtubules to both reduce growth rate and increase catastrophe frequency. They propose that this biochemical activity establishes a specialized compartment at the tip of the cilia where the activity the Gli family of Hh transcription factors is regulated.