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ERK 5 signaling gets XIAP ed: a role for ubiquitin in the disassembly of a MAPK cascade
Author(s) -
Klein Aileen M,
Cobb Melanie H
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201489205
Subject(s) - mapk/erk pathway , xiap , cobb , kinase , regulator , protein kinase a , biology , ubiquitin , apoptosis , microbiology and biotechnology , biochemistry , genetics , caspase , programmed cell death , gene
Mitogen‐activated protein kinase ( MAPK ) cascades are tightly controlled through a series of well‐characterized phospho‐regulatory events. In this issue, Takeda et al ([Takeda AN, 2014]) identify the inhibitor of apoptosis protein, XIAP , as a key regulator of ERK 5 activation via uncoupling of upstream kinase activity by non‐degradative ubiquitination.
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