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Deadenylation—a piece of PAN cake
Author(s) -
Stubbs Milton T,
Wahle Elmar
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201489136
Subject(s) - biology , exoribonuclease , microbiology and biotechnology , messenger rna , biochemistry , gene , rna , rnase p
Pan is a poly(A)‐specific 3′ exoribonuclease that, together with the CCR 4‐ NOT complex, is responsible for initiating and controlling mRNA decay by degradation of the poly(A) tail. Now, more than twenty years after the enzyme's discovery, a surge of recent papers, including one in this issue of The EMBO Journal (Wolf et al , [Wolf J, 2014]) has revealed details of its unusual asymmetric structure and aspects of its mode of substrate binding.