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Prion permissive pathways: extracellular matrix genes control susceptibility to prion infection
Author(s) -
Imberdis Thibaut,
Harris David A
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201489071
Subject(s) - biology , permissive , gene , extracellular matrix , permissiveness , extracellular , genetics , virology , prion protein , cell culture , microbiology and biotechnology , disease , viral replication , medicine , pathology
There are wide variations in the susceptibility of humans, animals, and cultured cell lines to infection by prions. In this issue of The EMBO Journal , Marbiah et al ([Marbiah MM, 2014]) identified a gene regulatory network that regulates the susceptibility of cultured cells to prion infection. Surprisingly, a number of these genes impact the structure of the extracellular matrix. These results have important implications for understanding mechanisms of prion infection and also suggest new therapeutic targets.