‘From blood to blood’: de‐differentiation of hematopoietic progenitors to stem cells | Zendy

Pereira CarlosFilipe | Zendy; Lemischka Ihor R | Zendy; Moore Kateri | Zendy

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‘From blood to blood’: de‐differentiation of hematopoietic progenitors to stem cells

Author(s) -

Pereira CarlosFilipe,

Lemischka Ihor R,

Moore Kateri

Publication year - 2014

Publication title -

the embo journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.484

H-Index - 392

eISSN - 1460-2075

pISSN - 0261-4189

DOI - 10.15252/embj.201488980

Subject(s) - biology , reprogramming , haematopoiesis , induced pluripotent stem cell , stem cell , progenitor cell , microbiology and biotechnology , blood cell , induced stem cells , cellular differentiation , immunology , cell , embryonic stem cell , genetics , gene

Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors ( TFs ) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al , 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long‐term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.

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