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‘From blood to blood’: de‐differentiation of hematopoietic progenitors to stem cells
Author(s) -
Pereira CarlosFilipe,
Lemischka Ihor R,
Moore Kateri
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201488980
Subject(s) - biology , reprogramming , haematopoiesis , induced pluripotent stem cell , stem cell , progenitor cell , microbiology and biotechnology , blood cell , induced stem cells , cellular differentiation , immunology , cell , embryonic stem cell , genetics , gene
Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors ( TFs ) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al , 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long‐term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.