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NAD + controls neural stem cell fate in the aging brain
Author(s) -
Wiley Christopher,
Campisi Judith
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201488969
Subject(s) - biology , neural stem cell , nad+ kinase , stem cell , mammalian brain , microbiology and biotechnology , biochemistry , neuroscience , enzyme
Loss of the coenzyme NAD + , which is required for many energy‐dependent cellular processes, has emerged as a potentially unifying mechanism for age‐related conditions. A study in this issue of The EMBO Journal identifies a novel link between depletion of NAD + and age‐associated loss of proliferating adult neural stem/progenitor cells in the murine brain (Stein & Imai, [Stein LR, 2014]). These data have important implications for how brain function might decline with age.