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Msp1: patrolling mitochondria for lost proteins
Author(s) -
Hegde Ramanujan S
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201488930
Subject(s) - biology , microbiology and biotechnology , mitochondrion , organelle , protein targeting , function (biology) , membrane protein , computational biology , genetics , membrane
Intracellular protein localization is critical for establishing organelle identity, avoiding inappropriate interactions, and maintaining cellular function. An emerging mechanism for ensuring high‐fidelity protein localization is the selective destruction of mislocalized copies. Two new papers find that the mitochondrial outer membrane is kept free of mislocalized proteins by Msp1 (Chen et al , [Chen YC, 2014]; Okreglak & Walter, [Okreglak V, 2014]).