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Wnt meets Warburg: another piece in the puzzle?
Author(s) -
Thompson Craig B
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201488785
Subject(s) - warburg effect , biology , anaerobic glycolysis , wnt signaling pathway , glycolysis , microbiology and biotechnology , mechanism (biology) , cancer cell , signal transduction , cancer , cancer research , genetics , metabolism , biochemistry , philosophy , epistemology
One of the most common abnormalities of cancer cells is their predilection to engage in a high rate of glycolysis despite the continued availability of oxygen. First described by Otto Warburg, this phenomenon of aerobic glycolysis (or the Warburg effect) has recently been proposed to result from cancer‐associated alterations in signal transduction pathways. In this issue of The EMBO Journal , Pate et al provide further support for this hypothesis by demonstrating that Wnt signaling plays an important role in establishing aerobic glycolysis as a mechanism to support in vivo cancer cell proliferation.