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The mRNA decay factor PAT 1 functions in a pathway including MAP kinase 4 and immune receptor SUMM 2
Author(s) -
Roux Milena Edna,
Rasmussen Magnus Wohlfahrt,
Palma Kristoffer,
Lolle Signe,
Regué Àngels Mateu,
Bethke Gerit,
Glazebrook Jane,
Zhang Weiping,
Sieburth Leslie,
Larsen Martin R,
Mundy John,
Petersen Morten
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201488645
Subject(s) - library science , biology , computer science
Multi‐layered defense responses are activated in plants upon recognition of invading pathogens. Transmembrane receptors recognize conserved pathogen‐associated molecular patterns ( PAMP s) and activate MAP kinase cascades, which regulate changes in gene expression to produce appropriate immune responses. For example, A rabidopsis MAP kinase 4 ( MPK 4) regulates the expression of a subset of defense genes via at least one WRKY transcription factor. We report here that MPK 4 is found in complexes in vivo with PAT 1, a component of the mRNA decapping machinery. PAT 1 is also phosphorylated by MPK 4 and, upon flagellin PAMP treatment, PAT 1 accumulates and localizes to cytoplasmic processing (P) bodies which are sites for mRNA decay. Pat1 mutants exhibit dwarfism and de‐repressed immunity dependent on the immune receptor SUMM 2. Since mRNA decapping is a critical step in mRNA turnover, linking MPK 4 to mRNA decay via PAT 1 provides another mechanism by which MPK 4 may rapidly instigate immune responses.