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A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles
Author(s) -
Sugiura Ayumu,
McLelland GianLuca,
Fon Edward A,
McBride Heidi M
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201488104
Subject(s) - pink1 , biology , mitophagy , microbiology and biotechnology , mitochondrial fusion , parkin , mitochondrial fission , mitochondrion , dnm1l , endosome , biogenesis , fis1 , peroxisome , vesicular transport protein , organelle , vesicle , mitochondrial dna , intracellular , biochemistry , disease , parkinson's disease , autophagy , gene , medicine , membrane , apoptosis , pathology
The last decade has been marked by tremendous progress in our understanding of the cell biology of mitochondria, with the identification of molecules and mechanisms that regulate their fusion, fission, motility, and the architectural transitions within the inner membrane. More importantly, the manipulation of these machineries in tissues has provided links between mitochondrial dynamics and physiology. Indeed, just as the proteins required for fusion and fission were identified, they were quickly linked to both rare and common human diseases. This highlighted the critical importance of this emerging field to medicine, with new hopes of finding drugable targets for numerous pathologies, from neurodegenerative diseases to inflammation and cancer. In the midst of these exciting new discoveries, an unexpected new aspect of mitochondrial cell biology has been uncovered; the generation of small vesicular carriers that transport mitochondrial proteins and lipids to other intracellular organelles. These mitochondrial‐derived vesicles ( MDV s) were first found to transport a mitochondrial outer membrane protein MAPL to a subpopulation of peroxisomes. However, other MDV s did not target peroxisomes and instead fused with the late endosome, or multivesicular body. The Parkinson's disease‐associated proteins Vps35, Parkin, and PINK 1 are involved in the biogenesis of a subset of these MDV s, linking this novel trafficking pathway to human disease. In this review, we outline what has been learned about the mechanisms and functional importance of MDV transport and speculate on the greater impact of these pathways in cellular physiology.