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K‐Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation
Author(s) -
Stilling Roman M,
Rönicke Raik,
Benito Eva,
Urbanke Hendrik,
Capece Vincenzo,
Burkhardt Susanne,
BahariJavan Sanaz,
Barth Jonas,
Sananbenesi Farahnaz,
Schütz Anna L,
Dyczkowski Jerzy,
MartinezHernandez Ana,
Kerimoglu Cemil,
Dent Sharon YR,
Bonn Stefan,
Reymann Klaus G,
Fischer Andre
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201487870
Subject(s) - biology , memory consolidation , histone acetyltransferase , acetyltransferase , hippocampal formation , pcaf , histone , synaptic plasticity , acetylation , microbiology and biotechnology , neuroscience , enhancer , p300 cbp transcription factors , gene expression , histone acetyltransferases , genetics , gene , hippocampus , receptor
Neuronal histone acetylation has been linked to memory consolidation, and targeting histone acetylation has emerged as a promising therapeutic strategy for neuropsychiatric diseases. However, the role of histone‐modifying enzymes in the adult brain is still far from being understood. Here we use RNA sequencing to screen the levels of all known histone acetyltransferases ( HAT s) in the hippocampal CA 1 region and find that K‐acetyltransferase 2a ( Kat2a) —a HAT that has not been studied for its role in memory function so far—shows highest expression. Mice that lack Kat2a show impaired hippocampal synaptic plasticity and long‐term memory consolidation. We furthermore show that Kat2a regulates a highly interconnected hippocampal gene expression network linked to neuroactive receptor signaling via a mechanism that involves nuclear factor kappa‐light‐chain‐enhancer of activated B cells ( NF ‐κB). In conclusion, our data establish Kat2a as a novel and essential regulator of hippocampal memory consolidation.