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Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells
Author(s) -
Wang Chiuhui Mary,
Ploia Cristina,
Anselmi Fabio,
Sarukhan Adelaida,
Viola Antonella
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201386666
Subject(s) - biology , paracrine signalling , microbiology and biotechnology , motility , adenosine triphosphate , priming (agriculture) , adenosine , immune system , cell signaling , second messenger system , autocrine signalling , t cell , uridine triphosphate , signal transduction , biochemistry , immunology , nucleotide , receptor , botany , germination , gene
Organization of immune responses requires exchange of information between cells. This is achieved through either direct cell–cell contacts and establishment of temporary synapses or the release of soluble factors, such as cytokines and chemokines. Here we show a novel form of cell‐to‐cell communication based on adenosine triphosphate ( ATP ). ATP released by stimulated T cells induces P2X4/P2X7‐mediated calcium waves in the neighboring lymphocytes. Our data obtained in lymph node slices suggest that, during T‐cell priming, ATP acts as a paracrine messenger to reduce the motility of lymphocytes and that this may be relevant to allow optimal tissue scanning by T cells.