Open AccessIs COVID-19 Fatality Rate Associated with Malaria Endemicity?
Author(s) -
Abdul Rehman Arshad,
Imtiaz Bashir,
Farhat Ijaz,
Nicholas Loh,
Suraj Shukla,
Ubaid ur Rehman,
Rana Khurram Aftab
Publication year - 2020
Publication title -
discoveries
Language(s) - English
Resource type - Journals
ISSN - 2359-7232
DOI - 10.15190/d.2020.17
Subject(s) - malaria , case fatality rate , covid-19 , coronavirus , pandemic , medicine , environmental health , disease , tropical medicine , virology , immunology , infectious disease (medical specialty) , outbreak , population , pathology
COVID-19 (coronavirus disease 2019) is a disease caused by the coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). COVID-19 has yielded many reported complications and unusual observations. In this article, we have reviewed one such observation: an association between malaria endemicity and reduced reported COVID-19 fatality. Malaria-endemic regions have a significantly lower reported COVID-19 fatality rate as compared to regions where malaria is non-endemic. Statistical analyses show that there is a strong negative correlation between the reported SARS-CoV-2 fatality and endemicity of malaria. In this review, we have discussed the potential role of CD-147, and potential malaria-induced immunity and polymorphisms in COVID-19 patients. Noteworthy, the results may also be due to underreported cases or due to the economic, political, and environmental differences between the malaria endemic and non-endemic countries. The study of this potential relationship might be of great help in COVID-19 therapy and prevention.