Open AccessCould the Next Antibiotic Emerge from Bacteria?
Author(s) -
Bichoy Labib
Publication year - 2019
Publication title -
sciential
Language(s) - English
Resource type - Journals
ISSN - 2562-1483
DOI - 10.15173/sciential.v1i2.2094
Subject(s) - effector , chaperone (clinical) , bacteria , secretion , biology , mechanism (biology) , microbiology and biotechnology , antibiotics , mechanism of action , computational biology , biochemistry , genetics , in vitro , medicine , philosophy , epistemology , pathology
An intrinsic bacterial mechanism could play a fundamental role in the future of antibiotics. Using cryo-EM, the structural resolution of the effector protein complexed with its chaperone and other accessory proteins reveals the mechanism of action of type VI bacterial secretion system. The importance of the chaperone protein, used to prime the toxic effector protein, was previously identified. Future research efforts should encompass the immunity protein that may allow bacteria to evade the lethal effects of this mechanism.