Open AccessVitamin D3-Loaded Nanostructured Lipid Carriers as a Potential Approach for Fortifying Food Beverages; in Vitro and in Vivo Evaluation
Author(s) -
Maryam Mohammadi,
Akram Pezeshki,
Mehran Mesgari Abbasi,
Babak Ghanbarzadeh,
Hamed Hamishehkar
Publication year - 2017
Publication title -
advanced pharmaceutical bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.773
H-Index - 35
eISSN - 2251-7308
pISSN - 2228-5881
DOI - 10.15171/apb.2017.008
Subject(s) - solid lipid nanoparticle , chemistry , nutraceutical , chromatography , particle size , homogenization (climate) , nanoparticle , vitamin , liposome , in vivo , food science , nanotechnology , biochemistry , materials science , microbiology and biotechnology , biodiversity , ecology , biology
Purpose: Nanostructured lipid carriers (NLCs) composed of solid lipid and oil are a new generation of lipid nanoparticles which have exhibited some merits over traditional used lipid nanoparticles in fortifying food and beverages and nutraceuticals delivery systems such as liposomes and solid lipid nanoparticles. Methods: In this study, Precirol and Compritol as solid lipids, Miglyol and Octyloctanoat as liquid lipids, Tween80, Tween20 and Poloxamer407 as surfactants were used to prepare vitamin D 3 -loaded NLC dispersion using hot homogenization method. The particle size and size distribution for all formulations were evaluated by immediately after production and during a storage period of 60 days. Results: The Precirol-based NLC showed superiority over Compritol-based NLC in the point of physical stability. Results clearly suggested that an optimum concentration of 3% of Poloxamer407 or 2% of Tween20 was sufficient to cover the surface of nanoparticles effectively and prevent agglomeration during the homogenization process. Octyloctanoat was introduced for the first time as a good substituent for Miglyol in the preparation of NLC formulations. The vitamin D 3 Intestinal absorption enhanced by the incorporating in NLCs. Conclusion: It was concluded that NLC showed a promising approach for fortifying beverages by lipophilic nutraceuticals such as vitamin D.