Open AccessSustained release Curcumin loaded Solid Lipid Nanoparticles
Author(s) -
Parisa Jourghanian,
Solmaz Ghaffari,
Mehdi Ardjmand,
Setareh Haghighat,
Mahdieh Mohammadnejad
Publication year - 2016
Publication title -
advanced pharmaceutical bulletin
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.773
H-Index - 35
eISSN - 2251-7308
pISSN - 2228-5881
DOI - 10.15171/apb.2016.04
Subject(s) - curcumin , solid lipid nanoparticle , bioavailability , chemistry , particle size , solubility , biocompatibility , antimicrobial , mannitol , chromatography , materials science , pharmacology , biochemistry , organic chemistry , medicine
curcumin is poorly water soluble drug with low bioavailability. Use of lipid systems in lipophilic substances increases solubility and bioavailability of poorly soluble drugs. The aim of this study was to prepare curcumin loaded Solid Lipid Nanoparticles (SLNs) with high loading efficiency, small particle size and prolonged release profile with enhanced antibacterial efficacy.