Open AccessCord Blood Mononuclear Cells Have a Potential to Produce NK Cells Using IL2Rg Cytokines
Author(s) -
Nahid Khaziri,
Seyede Momeneh Mohammadi,
Z Aliyari,
Jafar Soleimani Rad,
Hamid Tayefi Nasrabadi,
Hojjatollah Nozad Charoudeh
Publication year - 2016
Publication title -
advanced pharmaceutical bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.773
H-Index - 35
eISSN - 2251-7308
pISSN - 2228-5881
DOI - 10.15171/apb.2016.02
Subject(s) - peripheral blood mononuclear cell , cord blood , bone marrow , immunology , interleukin 21 , interleukin 12 , janus kinase 3 , interleukin 15 , cytokine , medicine , biology , interleukin , t cell , in vitro , immune system , cytotoxic t cell , biochemistry
Although bone marrow represents the main site for NK cell development and also distinct thymic-dependentNK cell pathway was identified, the cytokines effect on the NK cell generation from cord blood is unclear. Studies were identified the role of cytokines in the regulation of bone marrow and thymic NK cells. Previous studies reported that IL15 are critical for bone marrow dependent and IL7 is important for thymic NK cells. It is remain unclear the cytokines influence on the expantion of NK cells in cord blood mononuclear cells.